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Thursday, July 2, 2020

CanSino's COVID-19 Vaccine Candidate Approved for Military Use in China

By 
BEIJING — China's military has received the greenlight to use a COVID-19 vaccine candidate developed by its research unit and CanSino Biologics after clinical trials proved it was safe and showed some efficacy, the company said on Monday.
The Ad5-nCoV is one of China's eight vaccine candidates approved for human trials at home and abroad for the respiratory disease caused by the new coronavirus. The shot also won approval for human testing in Canada.
China's Central Military Commission approved the use of the vaccine by the military on June 25 for a period of one year, CanSino said in a filing. The vaccine candidate was developed jointly by CanSino and a research institute at the Academy of Military Science (AMS).
"The Ad5-nCoV is currently limited to military use only and its use cannot be expanded to a broader vaccination range without the approval of the Logistics Support Department," CanSino said, referring to the Central Military Commission department which approved the military use of the vaccine.

Tuesday, June 30, 2020

June 30, 2020- Broken hearted quotes


Sara Teasdale
“It is strange how often a heart must be broken before the years can make it wise.”

 
Miss Piggy
“Only time can heal your broken heart. Just as only time can heal his broken arms and legs.”

 
Christie Brinkley
“I’d rather have a broken arm than a broken heart.”

 
J.S.B. Morse
“A broken heart is just the growing pains necessary so that you can love more completely when the real thing comes along.”


Patti Roberts
“Every time your heart is broken, a doorway cracks open to a world full of new beginnings, new opportunities.”

Heidi Klum
“I’ve been heartbroken. I’ve broken hearts. That’s part of life, and it’s part of figuring out who you are so you can find the right partner.”


Toba Beta
“Heaven doesn’t ignore cries of a broken heart.”

Leo Buscaglia
“Let go. Why do you cling to pain? There is nothing you can do about the wrongs of yesterday. It is not yours to judge. Why hold on to the very thing which keeps you from hope and love?”

Aubrey Drake Graham
“One day you’re going to remember me and how much I loved you…then you’re gonna hate yourself for letting me go.”

Mandy Hale
“Sometimes it takes a heartbreak to shake us awake and help us see we are worth so much more than we’re settling for.”
 

Federico Chini
“With time the pain eases, the body recovers and the brain figures out new ways to go on.”


Sara Evans
“I know my heart will never be the same but I’m telling myself I’ll be okay.”


Mark Twain
“Never allow someone to be your priority while allowing yourself to be their option.”


Saturday, June 27, 2020

sanitizer spray pens


An unexpected boom? Demand for sanitizer spray pens shows strength of multifunctions

Posted: June 16, 2020
on GlobalSources.com

Sanitizer spray pens are currently among the top 20 most popular lifestyle products on GlobalSources.com in terms of buyer interest. But why?
Part of it is the coronavirus-driver high demand for hygiene and personal care products in general. But hand sanitizer spray pens are witnessing unprecedented growth, which other products are not. We can put some of that down to them being a new product – wind back the clock 10 or 20 years, and they simply don’t exist. So it’s a little easier for them to set records. But there’s more to it than that.
The rise in popularity of sanitizer pens among consumers is boosted by their practicality and convenience to be carried around, making them perfect for those on the move. They fit in your pocket or bag, but they still do the job a bulkier sanitizer spray bottle would do.
They’re also multifunctional. Which is to say, they’re still pens you can write with. And for that matter, press elevator buttons with. Don’t overlook this! People need to carry pens anyway, which means that a spray pen isn’t taking up extra space in your bag. It’s taking up space you already accounted for. Multifunctionality is a key differentiator in many product categories. Sometimes that comes off as bandwagon-jumping or simply a little random: witness the vast number of products that seemed to suddenly have Bluetooth speakers added to them starting around four years ago.
But when the use cases match, multifunctionality is practical and becomes attractive for consumers. And that’s what sanitizer spray pens do: they combine functions that are needed in the same scenarios – out around town, in the office – and the combined product is as portable as each single-function product would be separately.

These sanitizer spray pens are currently some of the top 20 most popular lifestyle products on GlobalSources.com –
Sunway Stationery & Gift Co.
Xiamen Premium Import & Export
Smartsing Trading Co.

Tuesday, June 23, 2020

June 23, 2020 - Dearest Papa Jack

Dearest papa jack John Gemperle
me mahal po ako, si aka catriona gray..pero hindi nya po ako mahal..kaso sexy po siya at masarap po siyang magluto ng menudo at angsarap po kainin ng ensaymada nya..gustong gusto ko po talaga kainin ang ensaymada nya..kaya hinahabol habol ko po siya kahit hindi nya ko mahal..
me mga ibang sexy at magagandang babae rin naman po na ramdam ko na mahal ako, kaso po hindi mga marunong magluto..ayoko po magutom..
sino po kaya ang ipupursue ko? medyo magastos naman po now if madami kang babae, kaya dapat isa na lang..
saan ka po ba? sa babaeng maganda, masarap magluto ng menudo at masarap ang ensaymada pero hindi ka mahal? OR sa babaeng maganda na mahal ka , pero hindi naman po marunong magluto? at walang maipakain sa yong ensaymada? kaya gutom ka pag kasama mo siya..
salamat po sa mag-aadvice,.
ang naguguluhan,
soldering soldering
#soldering

Monday, June 22, 2020

Ano ba reading para masabi na Highblood ka nga?


    in this time of pandemic, na kung ano-anong sakit nagsisilabasan, pero aligaga ka magpacheck up sa hospital gawa ng covid-19, pero hindi ko na matiis yung tension sa ulo at batok ko, so tinawagan ko na pinsan ko, pra medyo magtanong tanong so, ang unang una nya sinabi is if me mga nararamdaman mo if sakit or tension sa ulo or batok is baka ka highblood.. so naparesearch ako, ano ba talaga ang normal reading ng BP at ano yung considered na high blood pressure?
so ito ang lumabas sa google: 

Stages of hypertension for adults
Talk to your doctor about medication if these are your blood pressure numbers.
Systolic pressureDiastolic pressureStages of hypertension
180 or over120 or overhypertensive crisis
over 140over 90stage 2
130 to 13980 to 89stage 1

---

     so i need a BP meter, before, in the time of sulit.com.ph, we are selling online the automatic BP meter. so now, wala na kaming stocks nyan at ang tagal na nyan, so bumili nalang ako online sa lazada ng Omron BP meter - Omron JPN500 
  after a few days, immediately pagkadeliver sa gate ng lazada, i measured my BP.
 

 ito po ang resulta, sobrang taas!
  june 11, 2020 reading
  
so  tried to relax then measured again
 
 june 11, 2020 reading
---
today, june22,  i measured again, the reading is 131/90 , but my pulse rate is 102 ..
so based sa healthline, nasa stage 1 hypertension ako,,at pulse rate is very high nawalan kasi ng physical activity this lockdown.. hays
----
additional notes:

Blood pressure is determined by the amount of blood pumped by the heart and how easily blood flows through arteries. High blood pressure (hypertension) is when blood flows through your blood vessels with excessive force or pressure.
This is a common condition, but it shouldn’t be ignored. High blood pressure also increases the risk of heart disease.
Symptoms of severe high blood pressure can include:
Many of these symptoms don’t show until your blood pressure is dangerously high. It’s vital to regularly check your blood pressure to ensure your numbers stay within a healthy range.
Read on to learn what a healthy range is for adults, children, and pregnant women.

Blood pressure readings have two numbers. The top one is your systolic number (the pressure in your blood vessels when your heart contracts). The bottom one is your diastolic number (the pressure in your arteries when your heart relaxes between beats). The two numbers together show whether your blood pressure is healthy or unhealthy. A high systolic (130 and over) or diastolic (80 and over) can count as high blood pressure. But healthy numbers may also be different for adults, children, and pregnant women.

High blood pressure in adults

Healthy blood pressure in adults is a reading below 120 systolic and 80 diastolic. Blood pressure between 120 to 129 systolic and under 80 diastolic is considered elevated. Elevated blood pressure means you have a greater risk of developing high blood pressure later on. Your doctor may suggest eating less salt, eating a heart healthy diet, or living a more active lifestyle.

Stages of hypertension for adults

Talk to your doctor about medication if these are your blood pressure numbers.
Systolic pressureDiastolic pressureStages of hypertension
180 or over120 or overhypertensive crisis
over 140over 90stage 2
130 to 13980 to 89stage 1

---

 https://www.healthline.com/health/what-considered-high-blood-pressure#healthyreading

June 22, 2020


to Myself- imbes na magmukmok..pag Panget ka, daanin mo sa Sipag! stupid!

Saturday, June 20, 2020

Concrete Barrier, HINDI SAFE!

wag nyo laging isisi sa driver ang aksidente..from the very beginning, im not a fan of these concrete barriers..takaw aksidente talaga to..specially ni walang reflector..dapat po ang kalsada natin is paluwagin natin.. baligtad e.. pinapasikip pa using these concrete barriers , na ewan ko kung sino ba nakaisip..
Dapat if me women's rights, animal rights, human rights, consumer protection rights, me LGBTQRST rights,etc... dapat me driver's protection rights din group din..puro kasi concrete barriers, for me Plastic Cone ( na water-filled pra hindi tumumba) is a lot way safer pra sa lahat..
#mmda

Thursday, June 18, 2020

CORONA VIRUS COVID-19 VACCINE - WHERE ARE WE NOW? update ng Corona Virus Vaccine as of June 17, 2020


 Coronavirus Vaccine Tracker


PRECLINICAL
PHASE I
PHASE II
PHASE III
APPROVAL
125
8
8
2
0
Vaccines
not yet in
human trials
Vaccines
testing safety
and dosage
Vaccines
in expanded
safety trials
Vaccines
in large-scale
efficacy tests
Vaccines
approved
for use
Researchers around the world are developing more than 135 vaccines against the coronavirus. Vaccines typically require years of research and testing before reaching the clinic, but scientists are racing to produce a safe and effective vaccine by next year.

Antibody
produced in
response to a
vaccine
SARS-CoV-2
coronavirus
Work began in January with the deciphering of the SARS-CoV-2 genome. The first vaccine safety trials in humans started in March, but the road ahead remains uncertain. Some trials will fail, and others may end without a clear result. But a few may succeed in stimulating the immune system to produce effective antibodies against the virus.
Here is the status of all the vaccines that have reached trials in humans, along with a selection of promising vaccines still being tested in cells or animals.

The Vaccine Testing Process

The development cycle of a vaccine, from lab to clinic.

PRECLINICAL TESTING: Scientists give the vaccine to animals such as mice or monkeys to see if it produces an immune response.
PHASE I SAFETY TRIALS: Scientists give the vaccine to a small number of people to test safety and dosage as well as to confirm that it stimulates the immune system.
PHASE II EXPANDED TRIALS: Scientists give the vaccine to hundreds of people split into groups, such as children and the elderly, to see if the vaccine acts differently in them. These trials further test the vaccine’s safety and ability to stimulate the immune system.
PHASE III EFFICACY TRIALS: Scientists give the vaccine to thousands of people and wait to see how many become infected, compared with volunteers who received a placebo. These trials can determine if the vaccine protects against the coronavirus.
APPROVAL: Regulators in each country review the trial results and decide whether to approve the vaccine or not. During a pandemic, a vaccine may receive emergency use authorization before getting formal approval.
WARP SPEED: The U.S. government’s Operation Warp Speed program has selected five vaccine projects to receive billions of dollars in federal funding and support before there’s proof that the vaccines work.
COMBINED PHASES: Another way to accelerate vaccine development is to combine phases. Some coronavirus vaccines are now in Phase I/II trials, for example, in which they are tested for the first time on hundreds of people.

Genetic Vaccines

Vaccines that use one or more of the coronavirus’s own genes to provoke an immune response.

DNA
RNA
PHASE II WARP SPEED

Moderna’s vaccine dazzled the stock market in May with Phase I data on just eight people, only to see its stock price drop when experts had a lukewarm reaction to the results. The vaccine uses messenger RNA (mRNA for short) to produce viral proteins. Part of Operation Warp Speed, the American company is eyeing Phase III trials in July and hopes to have vaccines ready by early 2021.
PHASE I PHASE II WARP SPEED

The German company BioNTech has entered into collaborations with Pfizer, based in New York, and the Chinese drug maker Fosun Pharma to develop their mRNA vaccine. In May, Pfizer announced human trials for the vaccine. Another beneficiary of Operation Warp Speed, Pfizer hopes to have a few million doses for emergency use in the fall if all goes well in the trials.
PHASE I PHASE II

Imperial College London researchers have developed a “self-amplifying” RNA vaccine, which boosts production of a viral protein to stimulate the immune system. They began Phase I/II trials on June 15 and have partnered with Morningside Ventures to manufacture and distribute the vaccine through a new company called VacEquity Global Health.
PHASE I

In May, the American company Inovio published a study showing that their DNA-based vaccine produced antibodies in mice. Phase I trials are underway in the United States and will start in South Korea at the end of June.
PRECLINICAL

In March, the Trump administration tried to entice CureVac to move its research from Germany to the United States. On June 17, the company announced approval for a Phase I trial of its mRNA vaccine. The company said its German facility can make hundreds of millions of vaccines a year.

Viral Vector Vaccines

Vaccines that use a virus to deliver coronavirus genes into cells and provoke an immune response.
PHASE II PHASE III WARP SPEED

vaccine in development by the British-Swedish company AstraZeneca and the University of Oxford is based on a chimpanzee adenovirus called ChAdOx1. The vaccine is beginning Phase II/III testing in England and Brazil. Supported by Operation Warp Speed, the project may deliver emergency vaccines by October. In June, AstraZeneca said their total manufacturing capacity stands at two billion doses.
PHASE II

The Chinese company CanSino Biologics is testing a vaccine based on an adenovirus called Ad5, in partnership with the Institute of Biology at the country’s Academy of Military Medical Sciences. In May they published a paper in The Lancet, the first time Phase I trial data from any Covid-19 vaccine appeared in a scientific journal.
PRECLINICAL WARP SPEED

Researchers at Beth Israel Deaconess Medical Center in Boston are testing an adenovirus called Ad26 in monkeys. Johnson & Johnson, picked by Operation Warp Speed, announced in June that they would start Phase I/II trials in late July.
PRECLINICAL

The Swiss company Novartis will manufacture a vaccine based on a gene therapy treatment developed by the Massachusetts Eye and Ear Hospital. A virus called an adeno-associated virus delivers coronavirus gene fragments into cells. Phase I trials are set to begin in late 2020.
PRECLINICAL WARP SPEED

The American company Merck announced in May it would develop a vaccine from vesicular stomatitis viruses, the same approach it successfully used to produce the only approved vaccine for Ebola. The company is partnering with IAVI.
PRECLINICAL

Merck is also working with Themis Bioscience, an Austrian firm it is acquiring, to develop a second vaccine, which will use the measles virus to carry genetic material into patients’ cells.
PRECLINICAL

Vaxart’s vaccine is an oral tablet containing an adenovirus that delivers coronavirus genes. In June, the American company announced it was preparing for Phase I trials in summer 2020.

Protein-Based Vaccines

Vaccines that use a coronavirus protein or a protein fragment to provoke an immune response.
PHASE I PHASE II

In May, the Maryland-based Novavax started a Phase I/II trial on a vaccine made up of microscopic particles carrying fragments of coronavirus proteins. The Coalition for Epidemic Preparedness Innovations is investing $384 million in the project.
PHASE I

Clover Biopharmaceuticals has developed a vaccine containing a protein from coronaviruses. The vaccine would be taken in conjunction with a so-called adjuvant, made by the British drugmaker GSK, to further stimulate the immune system.
PRECLINICAL

After the SARS epidemic in 2002, Baylor College of Medicine researchers began developing a vaccine that could prevent a new outbreak. Despite promising early results, support for the research disappeared. Because the coronaviruses that cause SARS and Covid-19 are very similar, the researchers are reviving the project in partnership with the Texas Children’s Hospital.
PRECLINICAL

A vaccine in development by the University of Pittsburgh, called PittCoVacc, is a skin patch tipped with 400 tiny needles made of sugar. When placed on the skin, the needles dissolve and deliver virus proteins into the body.
PRECLINICAL

A vaccine from Australia’s University of Queensland delivers viral proteins altered to draw a stronger immune response. In June, the university and the company CSL announced a partnership to start Phase I trials, which could lead to millions of doses a year starting in 2021. GSK is providing an adjuvant to further stimulate the immune system.
PRECLINICAL

The French company Sanofi will produce viral proteins using engineered viruses that grow inside insect cells. GSK will supplement these proteins with adjuvants that stimulate the immune system. Sanofi has said it could produce at least 600 million doses a year if the vaccine succeeds in trials.

Whole-Virus Vaccines

Vaccines that use a weakened or inactivated version of the coronavirus to provoke an immune response.

Inactivated
virus
PHASE I PHASE II

The private Chinese company Sinovac Biotech is testing an inactivated vaccine called CoronaVac. On June 13 the company announced that Phase I/II trials on 743 volunteers found no severe adverse effects and produced an immune response. Sinovac is preparing Phase III trials in China and Brazil and is building a facility to manufacture up to 100 million doses annually.
PHASE I PHASE II

The state-owned Chinese company Sinopharm has started Phase I/II trials on two inactivated vaccine viruses. The company has announced it has built a facility in Beijing to make up to 200 million vaccines per year.
PHASE I

Researchers at the Institute of Medical Biology at the Chinese Academy of Medical Sciences, which has invented vaccines for polio and hepatitis A, are running a Phase I trial of an inactivated virus vaccine for Covid-19.

Repurposed Vaccines

Vaccines already in use for other diseases that may also protect against Covid-19.
PHASE III

The Bacillus Calmette-Guerin vaccine was developed in the early 1900s as a protection against tuberculosis. The Murdoch Children’s Research Institute in Australia is conducting a Phase III trial, and several other trials are underway to see if the vaccine partly protects against the coronavirus.

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